Im finking that there was some massive problem either threatening the shinigami or human world, most likely human, where Isshin falls in love with Ichigo's mom, and uses his own final getsuga tenshou, losing his powers, and instead does it the harder way than ichigo and waits around 15 years to get back to his former strength.
Whatever the problem is, Aizen will somehow escape, or from his prison, find a way to antagonize the same problem to occur again...
Calling upon Ichigo and Co.
Ginjou's team will be parred, and I fink that ichigo will just lose out, Ginjou will be forced to beat a hasty retreat, becuz he's kinda surrounded by captains of Gotei 13. He'll join up with Aizen, or free him, or in attempting to free him or the problem, will end up killing himself or getting killed by Aizen or the problem.
Expect the merging of Aizen and the problem
Oh yeah, and I do agree that it;s probably a fail of uruhas experiments...
GOOOOO PREDICTIONS! Whaddya fink?