*Charizard--didn't seem as bad the second time around, for some reason
*Steelix--I gave up on the game for about two months because of this guy
*Mr Mime--I gave up on the game for almost a year
*Final battle--I still haven't managed to beat it
The second game had its hard battles (Drapion was a pain), but overall it was a billion times easier. With a few exceptions, if you wiped out in a battle, you were just being careless.