So I'm guessing the '2' implies that these are sequels of Black and White. Given that, I'm assuming that BW2 are almost the Gold and Silver to BW's Red and Blue, albeit far more reductive. Since the Zekrom/Kyurem fusion is a mascot for Black, and vice versa for Reshiram, then this is obviously going to build on N, considering that in the original Black N was in possession of Zekrom (and, again, vice versa for Reshiram.)
N was generally reformed at the end of the past games, so it should be interesting to see how things transpire in this game.
Just continuing the parallels between RBY-GSE and BW-BW2, it would be interesting if we get new protagonists, and the old ones can be challenged in a Red-style battle at the end of the game. Who knows.