Here's my post from the beginning of March of my overly specific BW2 speculation:
As you can see, I've been predicting that we'll go east for a while now.I'm posting this simply so I'll have it recorded somewhere. And so I can claim victory if it turns out to be right.
Here's a guess as to the order in which we'll traverse Unova if this is a sequel (not including the post-game).
~Trains in the Battle Subway are no longer for battling, except for the train that goes in a circular route.
~The trains now lead to new areas of Unova. These areas will be unlocked throughout the game, some of which will involve the plot.
~Anville has three houses (like Nuvema) and has no real purpose in BW1 so it looks like a candidate to be the new starting town.
~The desert route and Twist Mountain will be different due to the construction in BW1.
~There will be a subway station either built in Striaton or where the Dreamyard was in BW1.
~To avoid repetition with BW1, we will not be battling the gym leaders throughout the main storyline BW2. Instead we will fight eight (probably evil) bosses. Gyms will be a post-game challenge.
~We will pursue the right half of the circular path in Unova since we took the left path in BW1. To enforce this, the Driftveil Drawbridge will be raised until after the credits.
~Since the right half of Unova will be a part of the main storyline, the plot will involve the Giant Chasm (coughKYUREMcough) and the Abyssal Ruins.
~The final showdown of the storyline will take place at one of the new locations of Unova accessible by the Subway (as opposed to the usual Pokemon League).
~In the post-game, the gyms will be accessible, and the left side of Unova will be open. After receiving all eight badges, you will be able to challenge the Pokemon League as per usual.
~Maybe, just maybe, the train in the Subway that leads up to the Pokemon League will lead to a special section of the League in which the Champions from the different regions challenge each other. Such a location was hinted-at in BW1 by Cynthia.
Huge stretch, just thought I'd have some fun in the speculation thread. Let me know what you think.