I wouldn't mind it if this region didn't have a "Team ____" running around. Having a couple different "bad" people would be a nice change. Hell, even having a villainous group that doesn't refer to themselves as "Team ____" would be phenomenal.
If there is a group of some kind, having their actions be especially sinister, like Pokemon experimentation or genetic alteration of Pokemon, would be quite interesting. To have to fight a villainous group outfitted with "hacked" Pokemon (which would revert to normal Pokemon if a cheat is used to catch them) would be a great challenge.